|Application ||WB, IHC-P, E|
|Calculated MW||17319 Da|
|Antigen Region||111-139 aa|
|Other Names||DAZ-associated protein 2, Deleted in azoospermia-associated protein 2, DAZAP2, KIAA0058|
|Target/Specificity||This DAZAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the C-terminal region of human DAZAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DAZAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm|
|Tissue Location||Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes Down-regulated in multiple myeloma.|
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Provided below are standard protocols that you may find useful for product applications.
DAZAP2 encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Kim, J.E., et al. Mol. Cell. Biol. 28(2):803-813(2008)
Shi, Y.W., et al. Chin. Med. J. 120(19):1659-1665(2007)
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