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RHBG Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H310 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49481 Da |
| Antigen Region | 423-450 aa |
| Gene ID | 57127 |
|---|---|
| Other Names | Ammonium transporter Rh type B, Rhesus blood group family type B glycoprotein, Rh family type B glycoprotein, Rh type B glycoprotein, RHBG |
| Target/Specificity | This RHBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-450 amino acids from the C-terminal region of human RHBG. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RHBG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RHBG (HGNC:14572) |
|---|---|
| Function | Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15284342, PubMed:15929723, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in kidney. Also detected in liver and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RHBG encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.
References
Han, K.H., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (1), L153-L163 (2009)
Brown, A.C., et al. Am. J. Physiol. Renal Physiol. 296 (6), F1279-F1290 (2009)
Sohet, F., et al. J. Biol. Chem. 283(39):26557-26567(2008)
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