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GFR alpha 3 Antibody

  • IF - GFR alpha 3 Antibody ASC10020
    Immunofluorescence of Trophinin in mouse liver tissue with Trophinin antibody at 20 µg/ml.
  • IHC - GFR alpha 3 Antibody ASC10020
    Immunohistochemistry of SOX2 in mouse brain tissue with SOX2 Antibodyat 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O35118
Other Accession NP_034410, 14587
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 44 kDa

Observed: 43 kDa
Application Notes GFR alpha 3 antibody can be used for detection of GFR alpha 3 expression by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Additional Information
Gene ID 14587
Other Names GFR alpha 3 Antibody: Y15110, GFRalpha3, GDNF family receptor alpha-3, GDNF receptor alpha-3, glial cell line derived neurotrophic factor family receptor alpha 3
Target/Specificity GFR alpha 3 antibody was raised against a 14 amino acid peptide near the center of murine GFR alpha 3.

The immunogen is located within the last 50 amino acids of GFR alpha 3.
Reconstitution & Storage GFR alpha 3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsGFR alpha 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Gfra3
Function Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Research Areas
Citations (0)

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GFR alpha 3 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified from human and mouse and designated GFRα-3. GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.


Milbrandt J, de Sauvage FJ, Fahrner TJ, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 1998; 20:245-253.
Nomeclature Committee. Nomeclature of GPI-linked receptors for the GDNF ligand family. GFRa. Neuron 1997; 19:485.
Jing S, Yu Y, Fang M, et al. GFRα-2 and GFRα-3 are two new receptors for ligands of the DGNF family. J. Biol. Chem. 1997; 272:33111-7.
Baloh RH, Gorodinsky A, Golden JP, et al. GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 1998; 95:5801-6.

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$ 330.00
Cat# ASC10020
Availability: 5-7days
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