Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Immunology   >   DcR2 Antibody   

DcR2 Antibody

  • WB - DcR2 Antibody ASC10041
    Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 µg/mL.
  • ICC - DcR2 Antibody ASC10041
    Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBN6
Other Accession Q9UBN6, 18203495
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 36 kDa

Observed: 36 kDa
Application Notes DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL.
Additional Information
Gene ID 8793
Other Names DcR2 Antibody: DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Target/Specificity TNFRSF10D;
Reconstitution & Storage DcR2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsDcR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart EMBL; AF029761; AAD03477.1; -; mRNA EMBL; AF021232; AAC32765.1; -; mRNA EMBL; AF021233; AAC32766.1; -; mRNA EMBL; AF023849; AAC52053.1; -; mRNA EMBL; AY358285; AAQ88652.1; -; mRNA EMBL; AK313528; BAG36307.1; -; mRNA EMBL; BC052270; AAH52270.1; -; mRNA CCDS; CCDS6038.1; - RefSeq; NP_003831.2; NM_003840.4 UniGene; Hs.213467; - ProteinModelPortal; Q9UBN6; - BioGrid; 114321; 6 DIP; DIP-6231N; - IntAct; Q9UBN6; 68 MINT; Q9UBN6; - STRING; 9606.ENSP00000310263; - iPTMnet; Q9UBN6; - PhosphoSitePlus; Q9UBN6; - SwissPalm; Q9UBN6; - BioMuta; TNFRSF10D; - DMDM; 18203495; - EPD; Q9UBN6; - MaxQB; Q9UBN6; - PaxDb; Q9UBN6; - PeptideAtlas; Q9UBN6; - PRIDE; Q9UBN6; - ProteomicsDB; 84018; - DNASU; 8793; - Ensembl; ENST00000312584; ENSP00000310263; ENSG00000173530 GeneID; 8793; - KEGG; hsa:8793; - UCSC; uc003xcz.4; human CTD; 8793; - DisGeNET; 8793; - EuPathDB; HostDB:ENSG00000173530.5; - GeneCards; TNFRSF10D; - H-InvDB; HIX0025539; - HGNC; HGNC:11907; TNFRSF10D HPA; HPA070971; - MIM; 603614; gene neXtProt; NX_Q9UBN6; - PharmGKB; PA36600; - eggNOG; ENOG410IZX0; Eukaryota eggNOG; ENOG4111ZZM; LUCA HOGENOM; HOG000142423; - HOVERGEN; HBG061626; - InParanoid; Q9UBN6; - KO; K22702; - OrthoDB; EOG091G0MOV; - PhylomeDB; Q9UBN6; - TreeFam; TF333916; - Reactome; R-HSA-202733; Cell surface interactions at the vascular wall Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands Reactome; R-HSA-75158; TRAIL signaling SignaLink; Q9UBN6; - SIGNOR; Q9UBN6; - ChiTaRS; TNFRSF10D; human GeneWiki; TNFRSF10D; - GenomeRNAi; 8793; - PRO; PR:Q9UBN6; - Proteomes; UP000005640; Chromosome 8 Bgee; ENSG00000173530; - CleanEx; HS_TNFRSF10D; - Genevisible; Q9UBN6; HS GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0045569; F:TRAIL binding; IEA:InterPro GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IBA:GO_Central GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:Reactome GO; GO:0006955; P:immune response; IBA:GO_Central GO; GO:0006954; P:inflammatory response; IBA:GO_Central GO; GO:0050900; P:leukocyte migration; TAS:Reactome GO; GO:0007275; P:multicellular organism development; IBA:GO_Central GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central GO; GO:0042981; P:regulation of apoptotic process; TAS:Reactome GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central GO; GO:0007165; P:signal transduction; TAS:ProtInc CDD; cd10580; TNFRSF10; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020465; TNFR_10 InterPro; IPR034024; TNFRSF10_N Pfam; PF00020; TNFR_c6; 2 PRINTS; PR01956; TNFACTORR10 SMART; SM00208; TNFR; 2 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 2 1: Evidence at protein level; Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 55 CHAIN 56 386 Tumor necrosis factor receptor superfamily member 10D /FTId=PRO_0000034584 TOPO_DOM 56 211 Extracellular. TRANSMEM 212 232 Helical. TOPO_DOM 233 386 Cytoplasmic. REPEAT 58 97 TNFR-Cys 1 REPEAT 98 139 TNFR-Cys 2 REPEAT 140 180 TNFR-Cys 3 DOMAIN 340 366 Death; truncated COMPBIAS 225 228 Poly-Val COMPBIAS 246 250 Poly-Gly CARBOHYD 127 127 N-linked (GlcNAc...) asparagine CARBOHYD 182 182 N-linked (GlcNAc...) asparagine DISULFID 83 96 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 99 115 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 118 131 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 121 139 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 141 155 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 158 172 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 162 180 {ECO:0000255|PROSITE-ProRule:PRU00206} VARIANT 35 35 P -> S (in TRAIL-R4-B; dbSNP:rs11135703) /FTId=VAR_011417 VARIANT 276 276 R -> H (in dbSNP:rs55636833) /FTId=VAR_061854 VARIANT 310 310 S -> L (in TRAIL-R4-B; dbSNP:rs1133782) /FTId=VAR_011418 VARIANT 345 345 T -> P (in dbSNP:rs34622674) /FTId=VAR_057288 SEQUENCE 386 AA; 41823 MW; 77A93577CAAF2632 CRC64; MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.


Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-3.
Pan G, Ni J, Wei YF, Yu G, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277:815-8.
Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997; 277:818-21.
Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 1997; 7:1003-6.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 330.00
Cat# ASC10041
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
“Crown Flash”  50 % off on 2,500+ Crown Antibodies. PromoCode:<span class=text-red> FLASH50
Terms & Conditions