|Application ||WB, IF, ICC, E|
|Other Accession||Q9UEE5, 14423930|
|Calculated MW||50 kDa|
|Application Notes||DRAK1 antibody can be used for detection of DRAK1 by Western blot at 1 µg/mL. An approximately 50 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 µg/mL. For immunofluorescence start at 10 µg/mL.|
|Other Names||DRAK1 Antibody: DRAK1, DRAK1, DAP kinase-related apoptosis-inducing protein kinase 1, serine/threonine kinase 17a|
|Target/Specificity||STK17A; No cross responses to DRAK2, DAP or ZIP kinases.|
|Reconstitution & Storage||DRAK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||DRAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.|
|Tissue Location||Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
DRAK1 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71
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