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AIF Antibody

  • WB - AIF Antibody ASC10094
    Western blot analysis of AIF in K562 cell lysate with AIF antibody at 1 µg/mL.
  • ICC - AIF Antibody ASC10094
    Immunocytochemistry of AIF in Jurkat cells with AIF antibody at 2 µg/mL.
  • IF - AIF Antibody ASC10094
    Immunofluorescence of AIF in K562 cells with AIF antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95381
Other Accession O95381, 50400606
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 67 kDa

Observed: 67 kDa
Application Notes AIF antibody can be used for detection of AIF by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 10256
Other Names AIF Antibody: CNK, KSR, CNK1, Connector enhancer of kinase suppressor of ras 1, CNK homolog protein 1, Connector enhancer of KSR 1, connector enhancer of kinase suppressor of Ras 1
Target/Specificity CNKSR1; Multiple isoforms of AIF are known to exist.
Reconstitution & Storage AIF antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsAIF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Citations (0)

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AIF Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed.


Zamzami N and Kroemer G. Condensed matter in cell death. Nature 1999; 401:127-8.
Sahara S, Aoto M, Eguchi Y, et al. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 1999; 401:168-73.

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$ 310.00
Cat# ASC10094
(40 western blots)
Availability: 5-7days
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