|Application ||WB, IHC-P, E|
|Other Accession||O75601, 10720034|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||43 kDa|
|Application Notes||Caspase-13 antibody can be used for detection of caspase-13 by Western blot at 1 µg/mL. A 43 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.|
|Other Names||Caspase-13 Antibody: CASP13, Caspase-13, Evolutionary related interleukin-1-beta-converting enzyme, CASP-13, caspase 4, apoptosis-related cysteine peptidase|
|Reconstitution & Storage||Caspase-13 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||Caspase-13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.|
|Tissue Location||Mainly expressed in peripheral blood lymphocytes, spleen and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Caspase-13 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7 (WD0500)
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