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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IRAK-M Antibody   

IRAK-M Antibody

  • WB - IRAK-M Antibody ASC10127
    Western blot analysis of IRAK-M in (M) mouse spleen and (R) rat liver tissue lysates with IRAK-M antibody at 1 µg/mL.
  • IHC - IRAK-M Antibody ASC10127
    Immunohistochemical staining of rat liver tissue using IRAK-M antibody at 2 µg/mL.
  • IF - IRAK-M Antibody ASC10127
    Immunofluorescence of IRAK-M in Rat Liver tissue with IRAK-M antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y616
Other Accession NP_009130, 5225377
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 66 kDa

Observed: 70 kDa
Application Notes IRAK-M antibody can be used for detection of IRAK-M by Western blot at 1 µg/mL. IRAK-M antibody can also detect IRAK-M by immunohistochemistry at 2 µg/mL. For immunofluorescence start at 10 µg/mL.
Additional Information
Gene ID 11213
Other Names IRAK-M Antibody: ASRT5, IRAKM, Interleukin-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M, IRAK-3, interleukin-1 receptor-associated kinase 3
Target/Specificity IRAK3; IRAK-M antibody is predicted to have no cross reactivity to other members of the IRAK family.
Reconstitution & Storage IRAK-M antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsIRAK-M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRAK3 {ECO:0000312|EMBL:AAH57800.1}
Function Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue Location Expressed predominantly in peripheral blood lymphocytes.
Research Areas
Citations (0)

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IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.


Cao Z, Henzel WJ, and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996; 271:1128-31.
Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5.
Wesche H, Gao X, Li X, et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999; 274:19403-10.

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$ 310.00
Cat# ASC10127
(40 western blots)
Availability: 5-7days
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