|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_065104, 9966841|
|Reactivity||Human, Mouse, Rat|
|Application Notes||Aven antibody can be used for detection of Aven by Western blot at 1 µg/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Other Names||Aven Antibody: PDCD12, Cell death regulator Aven, apoptosis, caspase activation inhibitor|
|Reconstitution & Storage||Aven antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||Aven Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects against apoptosis mediated by Apaf-1.|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes|
|Tissue Location||Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas EMBL; AF283508; AAF91470.1; -; mRNA EMBL; BC010488; AAH10488.1; -; mRNA EMBL; BC063533; AAH63533.1; -; mRNA CCDS; CCDS10030.1; - RefSeq; NP_065104.1; NM_020371.2 UniGene; Hs.555966; - ProteinModelPortal; Q9NQS1; - BioGrid; 121366; 10 IntAct; Q9NQS1; 5 MINT; MINT-143075; - STRING; 9606.ENSP00000306822; - iPTMnet; Q9NQS1; - PhosphoSitePlus; Q9NQS1; - BioMuta; AVEN; - DMDM; 20454834; - EPD; Q9NQS1; - MaxQB; Q9NQS1; - PaxDb; Q9NQS1; - PeptideAtlas; Q9NQS1; - PRIDE; Q9NQS1; - Ensembl; ENST00000306730; ENSP00000306822; ENSG00000169857 GeneID; 57099; - KEGG; hsa:57099; - UCSC; uc001zhj.4; human CTD; 57099; - DisGeNET; 57099; - GeneCards; AVEN; - HGNC; HGNC:13509; AVEN HPA; HPA020863; - MIM; 605265; gene neXtProt; NX_Q9NQS1; - OpenTargets; ENSG00000169857; - PharmGKB; PA134874337; - eggNOG; ENOG410IKTA; Eukaryota eggNOG; ENOG4111U7Z; LUCA GeneTree; ENSGT00390000003299; - HOGENOM; HOG000231429; - HOVERGEN; HBG024370; - InParanoid; Q9NQS1; - OMA; WDRYQDI; - OrthoDB; EOG091G0N3H; - PhylomeDB; Q9NQS1; - TreeFam; TF332067; - BioCyc; ZFISH:ENSG00000169857-MONOMER; - GenomeRNAi; 57099; - PMAP-CutDB; Q9NQS1; - PRO; PR:Q9NQS1; - Proteomes; UP000005640; Chromosome 15 Bgee; ENSG00000169857; - CleanEx; HS_AVEN; - ExpressionAtlas; Q9NQS1; baseline and differential Genevisible; Q9NQS1; HS GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell GO; GO:0005622; C:intracellular; IDA:UniProtKB GO; GO:0016020; C:membrane; IDA:UniProtKB GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB InterPro; IPR026187; Aven PANTHER; PTHR16524; PTHR16524; 1 1: Evidence at protein level; Apoptosis; Complete proteome; Membrane; Methylation; Phosphoprotein; Polymorphism; Reference proteome CHAIN 1 362 Cell death regulator Aven /FTId=PRO_0000064768 COMPBIAS 5 85 Ala/Gly-rich MOD_RES 94 94 Phosphoserine MOD_RES 230 230 N6-methyllysine VARIANT 228 228 Q -> R (in dbSNP:rs2241647) /FTId=VAR_020144 SEQUENCE 362 AA; 38506 MW; D86517BA087232D4 CRC64; MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM IS|
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Provided below are standard protocols that you may find useful for product applications.
Aven Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Chau BN, Cheng EH-Y, Kerr DA, et al. Aven, a novel inhibitor of caspase activation. Binds Bcl-xL and Apaf-1. Mol. Cell 2000; 6:31-40.
Paydas S, Tanriverdi K, Yavuz S, et al. Survivin and aven: two distinct antiapoptotic signals in acute leukemias. Ann. Oncology 2003; 14:1045-50.
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