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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL-21 Antibody   

IL-21 Antibody

  • WB - IL-21 Antibody ASC10142
    Western blot analysis of IL-21 expression in HL-60 cell lysate in (A) the absence or (B) the presence of blocking peptide with IL-21 antibody at 1 µg /ml.
  • ICC - IL-21 Antibody ASC10142
    Immunocytochemistry of IL-21 in K562 cells with IL-21 antibody at 2 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HBE4
Other Accession NP_068575, 11141875
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 18 kDa

Observed: 18 kDa
Application Notes IL-21 antibody can be used for detection of IL-21 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2 µg/mL.
Additional Information
Gene ID 59067
Other Names IL-21 Antibody: Za11, IL-21, Interleukin-21, Za11, interleukin 21
Target/Specificity IL21; At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.
Reconstitution & Storage IL-21 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsIL-21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL21
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Cellular Location Secreted.
Tissue Location Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
Research Areas
Citations (0)

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IL-21 Antibody: A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.


Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000; 408:57-63.
Ozaki K, Kikly K, Michalovich D, et al.  Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc. Natl. Acad. Sci. USA. 2000; 97:11439-44.
Asao H, Okuyama C, Kumaki S, et al. The common γ-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 2001; 167:1-5.

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$ 310.00
Cat# ASC10142
(40 western blots)
Availability: 5-7days
Bulk Size
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