|Application ||WB, IHC-P, IF, E|
|Other Accession||Q15041, 14424435|
|Calculated MW||23363 Da|
|Application Notes||ARMER antibody can be used for detection of ARMER by Western blot at 0.5 to 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 µg/mL. For immunofluorescence start at 2 µg/mL.|
|Other Names||ARMER Antibody: AIP1, ARMER, SPG61, ARL6IP, KIAA0069, ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1, ADP-ribosylation factor-like 6 interacting protein 1|
|Reconstitution & Storage||ARMER antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ARMER Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.|
|Cellular Location||Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Predominantly localized to intracytoplasmic membranes|
|Tissue Location||Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.|
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Provided below are standard protocols that you may find useful for product applications.
ARMER Antibody: Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Stellar H. Mechanisms and genes of cellular suicide. Science 1995; 267:1445-9.
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 2000; 403:98-103.
Lui HM, Chen J, Wang L, et al. ARMER, Apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol. Cancer Res. 2003; 1:508-18.
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