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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SIGIRR Antibody   

SIGIRR Antibody

  • WB - SIGIRR Antibody ASC10260
    Western blot analysis of SIGIRR in A549 cell lysate with SIGIRR antibody at (A) 0.5, (B) 1, and (C) 2 µg/mL.
  • ICC - SIGIRR Antibody ASC10260
    Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6IA17
Other Accession CAG33619, 48146793
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 45679 Da
Application Notes SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 0.5 to 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL.
Additional Information
Gene ID 59307
Other Names SIGIRR Antibody: TIR8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Target/Specificity SIGIRR;
Reconstitution & Storage SIGIRR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSIGIRR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Cellular Location Membrane; Single-pass type III membrane protein
Tissue Location Mainly expressed in epithelial tissues such as kidney, lung and gut.
Research Areas
Citations (0)

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SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.


Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
Thomassen E, Renshaw BR, and Sims JE. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 1999; 11:389-99.
Wald D, Qin J, Zhao Z, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 2003; 4:920-7.

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$ 310.00
Cat# ASC10260
(40 western blots)
Availability: 5-7days
Bulk Size
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