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TAB3 Antibody

  • IHC - TAB3 Antibody ASC10268
    Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N5C8
Other Accession NP_690000, 98991767
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 78683 Da
Application Notes TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 µg/mL.
Additional Information
Gene ID 257397
Other Names TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3, TGF-beta activated kinase 1/MAP3K7 binding protein 3
Target/Specificity TAB3; TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
Reconstitution & Storage TAB3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTAB3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB3
Synonyms MAP3K7IP3
Function Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Tissue Location Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
Research Areas
Citations (0)

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TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.


Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34.
Besse A, Lamothe B, Campos AD, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. 2007; 282:3918-28.
Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.

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$ 310.00
Cat# ASC10268
(40 western blots)
Availability: 5-7days
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