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TRBP1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13395 |
| Other Accession | NP_005637, 110825988 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 181675 Da |
| Application Notes | TRBP1 antibody can be used for detection of TRBP1 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 6894 |
|---|---|
| Other Names | TRBP1 Antibody: TRM3, TRP185, TRP-185, TRM3, Probable methyltransferase TARBP1, TAR RNA-binding protein 1, TAR (HIV-1) RNA binding protein 1 |
| Target/Specificity | TARBP1; |
| Reconstitution & Storage | TRBP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TRBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TARBP1 |
|---|---|
| Synonyms | TRM3, TRP185 |
| Function | Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRBP1 Antibody: The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1α (EF-1α), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
References
Gatignol A, Buckler-White A, Berkhout B, et al. Characterization of a human TAR REN-binding protein that activates the HIV-1 LTR. Science 1991; 251:1597-1600.
Wu-Baer F, Lane WS, and Gaynor RB. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J. Biol. Chem.1996; 271:4201-8.
Wu-Baer F, Lane WS, and Gaynor RB. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995; 14:5995-6009.
(07-01D)
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