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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NPTX2 Antibody   

NPTX2 Antibody

     
  • IF - NPTX2 Antibody ASC10682
    Immunofluorescence of Chk2 in Jurkat cells with Chk2 antibody at 5 µg/mL
  • WB - NPTX2 Antibody ASC10682
    Western blot analysis of ERRF in (A) HeLa and (B) A-20 cell lysate with ERRF antibody at 1 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P47972
Other Accession NP_002514, 4885
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 47042 Da
Application Notes NPTX2 antibody can be used for detection of NPTX2 by Western blot at 0.5 and 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Additional Information
Gene ID 4885
Target/Specificity NPTX2 antibody was raised against a 16 amino acid synthetic peptide near the center of the human NPTX2.

The immunogen is located within amino acids 170 - 220 of NPTX2.
Reconstitution & Storage NPTX2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNPTX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPTX2
Function Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
Cellular Location Secreted.
Tissue Location Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis
Research Areas
Citations (0)

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Background

NPTX2 Antibody: Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.

References

Hsu YC and Perin MS. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. Genomics1995; 28:220-7.
Tsu CC, Copeland GG, Gilbert DJ, et al. Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. J. Neurosci.1996; 16:2463-78.
Xu D, Hopf C, Reddy R, et al. Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron2003; 39:513-28.
Moran LB, Hickey L, Michael GJ, et al. Neuronal pentraxin II is highly upregulated in Parkinson’s disease and a novel component of Lewy bodies. Acta Neuropathol.2008; 115:471-8.

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$ 320.00
Cat# ASC10682
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