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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RCAN2 Antibody   

RCAN2 Antibody

     
  • WB - RCAN2 Antibody ASC10857
    Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - RCAN2 Antibody ASC10857
    Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 µg/mL.
  • IF - RCAN2 Antibody ASC10857
    Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9JHG2
Other Accession AAH62141, 38328420
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 22025 Da
Application Notes RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 53901
Target/Specificity Rcan2;
Reconstitution & Storage RCAN2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsRCAN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Rcan2
Synonyms Dscr1l1, Zaki4
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue Location Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues
Research Areas
Citations (0)

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Background

RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

References

Miyazaki T, Kanou Y, Murata Y, et al. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J. Biol. Chem.1996; 271:14567-71.
Rothermal B, Vega RB, Yang J, et al. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem.2000; 275:8719-25.
Cao X, Kambe F, Miyazaki Y, et al. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem. J.2002; 367:459-66.
Fuentes JJ, Genesca L, Kingsbury TJ, et al. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet.2000; 9:1681-90.

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$ 310.00
Cat# ASC10857
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(40 western blots)
Availability: 5-7days
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