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MC4R Antibody

  • WB - MC4R Antibody ASC10917
    Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - MC4R Antibody ASC10917
    Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 µg/mL.
  • IF - MC4R Antibody ASC10917
    Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32245
Other Accession NP_005903, 119508433
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 36943 Da
Application Notes MC4R antibody can be used for detection of MC4R by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 4160
Target/Specificity MC4R;
Reconstitution & Storage MC4R antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsMC4R Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MC4R
Function Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Brain, placental, and gut tissues.
Research Areas
Citations (0)

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MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.


Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem.1993; 268:15174-9.
Vongs A, Lynn NM, and Rosenblum CI. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept.2004; 120:113-8.
Cone H. Anatomy and regulation of the central melanocortin system. Nat. Neurosci.2005; 8:571-8.
Chai B, Li J-Y, Zhang W, et al. Melanocartin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides2009; 30:1098-10

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$ 310.00
Cat# ASC10917
(40 western blots)
Availability: 5-7days
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