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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HAAO Antibody   

HAAO Antibody

  • WB - HAAO Antibody ASC10937
    Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 µg/mL.
  • IHC - HAAO Antibody ASC10937
    Immunohistochemistry of HAAO in human liver tissue with HAAO antibody at 2.5 µg/mL.
  • IF - HAAO Antibody ASC10937
    Immunofluorescence of HAAO in Human Liver cells with HAAO antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46952
Other Accession NP_036337, 188497625
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32556 Da
Application Notes HAAO antibody can be used for detection of HAAO by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 23498
Target/Specificity HAAO;
Reconstitution & Storage HAAO antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsHAAO Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAAO {ECO:0000255|HAMAP-Rule:MF_03019}
Function Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.


Decker RH, Kang HH, Leach FR, et al. Purification and properties of 3-hydroxyanthranilic acid oxidase. J. Biol. Chem.1961; 236:3076-82.
Huang YW, Jansen RA, Fabbri E, et al. Identification of candidate epigenetic biomarkers for ovarian cancer detection. Oncol. Rep.2009; 22:853-61.

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$ 310.00
Cat# ASC10937
(40 western blots)
Availability: 5-7days
Bulk Size
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