|Application ||WB, E|
|Other Accession||NP_001092909, 150456460|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||109716 Da|
|Application Notes||EphA10 antibody can be used for detection of EphA10 by Western blot at 1 - 2 µg/mL.|
|Reconstitution & Storage||EphA10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||EphA10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 2: Secreted.|
|Tissue Location||Mainly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
EphA10 Antibody: Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.
Flanagan JG and Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci.1998;.21:309-45.
Frisen J, Holmberg J, and Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J.1999; 18:5159-65.
Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell1997; 90:403-4.
Holder N and Klein R. Eph receptors and ephrins: effectors of morphogenesis, Development1999; 126:2033-44.
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