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OCIAD1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9NX40 |
| Other Accession | NP_060300, 8923427 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 27626 Da |
| Application Notes | OCIAD1 antibody can be used for detection of OCIAD1 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 54940 |
|---|---|
| Target/Specificity | OCIAD1; |
| Reconstitution & Storage | OCIAD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | OCIAD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OCIAD1 (HGNC:16074) |
|---|---|
| Function | Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946). |
| Cellular Location | Endosome {ECO:0000250|UniProtKB:Q9CRD0}. |
| Tissue Location | Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord |
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Provided below are standard protocols that you may find useful for product applications.
Background
OCIAD1 Antibody: OCIAD1 was identified via immunoscreening of an ovarian carcinoma cDNA library from ovarian cancer patients and is expressed in multiple tissues including ovary, placenta, brain, testis, prostate, and mammary gland. Two isoforms of OCIAD1 are known to exist; the shorter isoform is restricted to the central nervous system. OCIAD1 is a transmembrane protein whose overexpression in HEY ovarian cancer cells increased lysophosphatidic acid- (LPA-)induced, but not basal level cell adhesion to extracellular matrix proteins collagen I and laminin10/11. This adhesion is not blocked by LY294002 and GF109203X, suggesting that OCIAD1 does not use protein kinase C and PI3 kinase signaling pathways to exert its effect on adhesion.
References
Luo LY, Soosaipillai A, and Diamandis EP. Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library. Biochem. Biophys. Res. Commun.2001; 280:401-6.
Sengupta S, Michener CM, Escobar P, et al. Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. Gynecologic Oncol.2008; 109:226-33.
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