|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_006298, 5454086|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||51572 Da|
|Application Notes||SRPX1 antibody can be used for detection of SRPX1 by Western blot at 0.25 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||SRPX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SRPX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.|
|Cellular Location||Cell surface. Note=Possibly surface of photoreceptor cell|
|Tissue Location||Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain|
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Provided below are standard protocols that you may find useful for product applications.
SRPX1 Antibody: SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
Dry KL, Aldred MA, Edgar AJ, et al. Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retinitis pigmentosa (RP3). Hum. Mol. Genet.1995; 4:2347-53.
Iragavarapu S, Algeciras ME, Lee RK, et al. ETX1 is over-expressed in the glaucomatous trabecular meshwork. Mol. Vision2009; 15:2061-7.
Shimakage M, Kawahara K, Kikkawa N, et al. Downregulation of drs mRNA in human colon adenocarcinomas. Int. J. Cancer2000; 87:5-11.
Tambe Y, Isono T, Haraguchi S, et al. A novel apoptotic pathway induced by the drs tumor suppressor gene. Oncogene2004; 23:2977-87.
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