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PLEKHM3 Antibody

  • IHC - PLEKHM3 Antibody ASC11017
    Immunohistochemistry of PLEKHM3 in human brain tissue with PLEKHM3 antibody at 5 µg/mL.
  • IF - PLEKHM3 Antibody ASC11017
    Immunofluorescence of PLKHM3 in human brain tissue with PLKHM3 antibody at 20 µg/mL.
  • WB - PLEKHM3 Antibody ASC11017
    Western blot analysis of PLEKHM3 in mouse skeletal muscle tissue lysate with PLEKHM3 antibody at (A) 1 and (B) 2 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZWE6
Other Accession Q6ZWE6, 172046173
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 87166 Da
Application Notes PLEKHM3 antibody can be used for detection of PLEKHM3 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 389072
Target/Specificity PLEKHM3;
Reconstitution & Storage PLEKHM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsPLEKHM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLEKHM3 (HGNC:34006)
Function Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8BM47}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BM47}. Cell membrane {ECO:0000250|UniProtKB:Q8BM47}. Note=Before differentiation of muscle cells, localized to the Golgi apparatus. During muscle differentiation shuttles to the plasma membrane {ECO:0000250|UniProtKB:Q8BM47}
Research Areas
Citations (0)

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PLEKHM3 Antibody: PLEKHM3, also known as DAPR, is a member of the M family of Pleckstrin homology domain-containing proteins. PLEKHM3 was initially identified through chromatin immunoprecipitation and CpG microarray analysis examining proteins regulated by myocyte-enhancing factor 2. In C2C12 myoblast cells, PLEKHM3 binds to the PI3K signaling member protein kinase B in the cytosol prior to differentiation into myotubes. Following the initiation of differentiation, PLEKHM3 was also found in membrane fractions. Knockdown of PLEKHM3 expression by RNAi resulted in the inhibition of myotube formation, suggesting that PLEKHM3 is a key component required by myoblasts for orchestrating their differentiation during myogenesis.


Virtanen C, Paris J, and Takahashi M. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. J. Biol. Chem.2009; 284:1636-43.

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$ 330.00
Cat# ASC11017
Availability: 5-7days
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