|Application ||WB, E|
|Other Accession||NP_976248, 42766424|
|Calculated MW||Predicted: 32 kDa |
Observed: 33 kDa
|Application Notes||FAM212A antibody can be used for detection of FAM212A by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||FAM212A; FAM212A antibody is human and mouse . At least two isoforms of FAM212A are known to exist; this antibody will recognize both isoforms.|
|Reconstitution & Storage||FAM212A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||FAM212A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847).|
|Cellular Location||Nucleus. Cytoplasm. Note=Mainly nuclear (PubMed:26607847). Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847)|
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Provided below are standard protocols that you may find useful for product applications.
FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives (1). FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics (1). In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly (2).
Luo T, Xu Y, Hoffman TL, et al. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Dev. 2007; 134:1279-89.
Reid BS, Sargent TD, and Willams T. Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev. Dyn. 2010; 239:1188-96.
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