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FAM212A Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EL1 |
| Other Accession | NP_976248, 42766424 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 32 kDa Observed: 33 kDa |
| Application Notes | FAM212A antibody can be used for detection of FAM212A by Western blot at 1 - 2 µg/ml. |
| Gene ID | 389119 |
|---|---|
| Target/Specificity | FAM212A; FAM212A antibody is human and mouse . At least two isoforms of FAM212A are known to exist; this antibody will recognize both isoforms. |
| Reconstitution & Storage | FAM212A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | FAM212A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INKA1 (HGNC:32480) |
|---|---|
| Function | Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). |
| Cellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear (PubMed:26607847) Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847). |
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Provided below are standard protocols that you may find useful for product applications.
Background
FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives (1). FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics (1). In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly (2).
References
Luo T, Xu Y, Hoffman TL, et al. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Dev. 2007; 134:1279-89.
Reid BS, Sargent TD, and Willams T. Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev. Dyn. 2010; 239:1188-96.
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