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ZSCAN4 Antibody

  • WB - ZSCAN4 Antibody ASC11070
    Western blot analysis of ZSCAN4 in mouse lung tissue lysate with ZSCAN4 antibody in (A) the absence and (B) presence of blocking peptide.
  • IHC - ZSCAN4 Antibody ASC11070
    Immunohistochemistry of ZSCAN4 in rat lung tissue with ZSCAN4 antibody at 5 µg/mL.
  • IF - ZSCAN4 Antibody ASC11070
    Immunofluorescence of ZSCAN4 in Rat Lung tissue with ZSCAN4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NAM6
Other Accession NP_689890.1, 22749365
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 48 kDa

Observed: 64 kDa
Application Notes ZSCAN4 antibody can be used for detection of ZSCAN4 by Western blot. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 201516
Target/Specificity ZSCAN4;
Reconstitution & Storage ZSCAN4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZSCAN4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ZNF494
Function Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00187}. Chromosome, telomere EMBL; AK092424; BAC03886.1; -; mRNA EMBL; BC101738; AAI01739.1; -; mRNA EMBL; BC101740; AAI01741.1; -; mRNA CCDS; CCDS12958.1; - RefSeq; NP_689890.1; NM_152677.2 RefSeq; XP_011524909.1; XM_011526607.2 RefSeq; XP_016881947.1; XM_017026458.1 UniGene; Hs.469663; - ProteinModelPortal; Q8NAM6; - SMR; Q8NAM6; - BioGrid; 128392; 3 IntAct; Q8NAM6; 5 MINT; Q8NAM6; - STRING; 9606.ENSP00000321963; - iPTMnet; Q8NAM6; - PhosphoSitePlus; Q8NAM6; - BioMuta; ZSCAN4; - DMDM; 55976744; - PaxDb; Q8NAM6; - PeptideAtlas; Q8NAM6; - PRIDE; Q8NAM6; - ProteomicsDB; 72681; - DNASU; 201516; - Ensembl; ENST00000318203; ENSP00000321963; ENSG00000180532 Ensembl; ENST00000612521; ENSP00000480210; ENSG00000180532 GeneID; 201516; - KEGG; hsa:201516; - UCSC; uc002qpu.3; human CTD; 201516; - EuPathDB; HostDB:ENSG00000180532.10; - GeneCards; ZSCAN4; - HGNC; HGNC:23709; ZSCAN4 HPA; HPA006491; - MIM; 613419; gene neXtProt; NX_Q8NAM6; - OpenTargets; ENSG00000180532; - PharmGKB; PA134878313; - eggNOG; KOG1721; Eukaryota eggNOG; COG5048; LUCA GeneTree; ENSGT00390000012244; - HOGENOM; HOG000146439; - HOVERGEN; HBG067140; - InParanoid; Q8NAM6; - KO; K09230; - OMA; NSYARQE; - OrthoDB; EOG091G06IX; - PhylomeDB; Q8NAM6; - TreeFam; TF337216; - GenomeRNAi; 201516; - PRO; PR:Q8NAM6; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000180532; - CleanEx; HS_ZSCAN4; - Genevisible; Q8NAM6; HS GO; GO:0000784; C:nuclear chromosome, telomeric region; ISS:UniProtKB GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0045950; P:negative regulation of mitotic recombination; ISS:BHF-UCL GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd07936; SCAN; 1 Gene3D; 1.10.4020.10; -; 1 InterPro; IPR003309; SCAN_dom InterPro; IPR038269; SCAN_sf InterPro; IPR036236; Znf_C2H2_sf InterPro; IPR013087; Znf_C2H2_type Pfam; PF02023; SCAN; 1 SMART; SM00431; SCAN; 1 SMART; SM00355; ZnF_C2H2; 4 SUPFAM; SSF57667; SSF57667; 2 PROSITE; PS50804; SCAN_BOX; 1 PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4 PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4 2: Evidence at transcript level; Chromosome; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Telomere; Transcription; Transcription regulation; Zinc; Zinc-finger CHAIN 1 433 Zinc finger and SCAN domain-containing protein 4 /FTId=PRO_0000047751 DOMAIN 44 126 SCAN box. {ECO:0000255|PROSITE- ProRule:PRU00187} ZN_FING 312 334 C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 340 362 C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 368 390 C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042} ZN_FING 396 418 C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042} VARIANT 387 387 E -> K (in dbSNP:rs11668570) /FTId=VAR_052926 SEQUENCE 433 AA; 48957 MW; 2B3061C197F2D388 CRC64; MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK ITLPSVPSTP EAS
Citations (0)

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ZSCAN4 Antibody: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.


Hamatani T, Carter MG, Sharov AA, et al. Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 2004; 6:117-131.
Falco G, Lee SL, Stanghellini I, et al. Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev. Biol. 2007; 307:539-50.
Zalzman M, Falco G, Sharova LV, et al. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 2010; 464:858-63.

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$ 330.00
Cat# ASC11070
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