Slc37A2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | Q8TED4 |
Other Accession | NP_938018, 38093649 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 54436 Da |
Application Notes | Slc37A2 antibody can be used for detection of Slc37A2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Gene ID | 219855 |
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Target/Specificity | SLC37A2; |
Reconstitution & Storage | Slc37A2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | Slc37A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC37A2 (HGNC:20644) |
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Function | Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Detected in intestine and pancreas. Lower expression is also detected in liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
Slc37A2 Antibody: The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75kDa.
References
Bartolini L and Antonarakis SE. The human sugar-phosphate/phosphate exchanger family SLC37. Eur. J. Physiol.2004; 447-780-3.
Kim JY, Tillison K, Zhou S, et al. The major facilitator superfamily member Slc37a2 is a novel macrophage-specific gene selectively expressed in obese white adipose tissue. Am. J. Physiol. Endocrinol. Metab.2007; 293:E110-20.
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