|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_036396, 63259329|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||45562 Da|
|Application Notes||TMEM184B antibody can be used for detection of TMEM184B by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||TMEM184B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TMEM184B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May activate the MAP kinase signaling pathway.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
TMEM184B Antibody: TMEM184B, also known as C22orf5, is a 407 amino acid multi-pass membrane protein and represents a novel gene in the activation of the MAPK signaling pathway. The gene encoding TMEM184B maps to human chromosome 22; mutations in several of the genes in chromosome 22 are involved in the development of autism, schizophrenia, Phelan-McDermid syndrome and Neurofibromatosis type 2, suggesting that TMEM184B may play a role in these syndromes.
Matsuda A, Suzuki Y, Honda G, et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene2003; 22:3307-18.
Dunham I, Shimizu N, Roe BA, et al. The DNA sequence of human chromosome 2. Nature1999; 402:489-495.
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