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ENC-1 Antibody

  • WB - ENC-1 Antibody ASC11107
    Western blot analysis of ENC-1 in mouse kidney muscle tissue lysate with ENC-1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - ENC-1 Antibody ASC11107
    Immunohistochemistry of ENC-1 in rat kidney tissue with ENC-1 antibody at 5 µg/mL.
  • IF - ENC-1 Antibody ASC11107
    Immunofluorescence of ENC-1 in rat kidney tissue with ENC-1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14682
Other Accession O14682, 12644050
Reactivity Human, Mouse, Rat
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 66130 Da
Application Notes ENC-1 antibody can be used for detection of ENC-1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 8507
Target/Specificity ENC1;
Reconstitution & Storage ENC-1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsENC-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENC1
Synonyms KLHL37, NRPB, PIG10
Function Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism.
Cellular Location Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton
Tissue Location Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down- regulated in neuroblastoma tumors
Research Areas
Citations (0)

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ENC-1 Antibody: The ectoderm-neural cortex-1 (ENC-1) protein is an early and highly specific marker of neural induction in vertebrates. It is a kelch family related protein that functions as an actin-binding protein and has been suggested to be involved in the organization of the actin cytoskeleton during neural fate specification and development of the nervous system. ENC-1 has also been shown to be required for adipocyte differentiation when cytoskeletal reorganization and cell shape change from fibroblastic preadipocytes to spherical adipocytes occur.


Hernandez MC, Andres-Barquin PJ, Martinez S, et al. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. J. Neurosci.1997; 17:3038-51.
Zhao L, Gregoire F and Sul HS. Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation. J. Biol. Chem.2000; 275:16845-50.

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$ 310.00
Cat# ASC11107
(40 western blots)
Availability: 5-7days
Bulk Size
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