|Application ||WB, IF, ICC, E|
|Other Accession||NP_659444, 194018484|
|Calculated MW||117779 Da|
|Application Notes||NALP11 antibody can be used for detection of NALP11 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||NALP11 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||NALP11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP11, NOD17, PAN10, PYPAF6|
|Function||Involved in inflammation.|
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Provided below are standard protocols that you may find useful for product applications.
NALP11 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP11, it has been suggested that it has been associated with Crohn's disease.
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Cummings JR, Cooney RM, Clarke G, et al. The genetics of NOD-like receptors in Crohn’s disease. Tiss. Antigens2010; 76:48-56.
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