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ZIP2 Antibody

  • WB - ZIP2 Antibody ASC11244
    Western blot analysis of ZIP2 in rat brain tissue lysate with ZIP2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - ZIP2 Antibody ASC11244
    Immunohistochemistry of ZIP2 in human brain tissue with ZIP2 antibody at 2.5 µg/mL.
  • IF - ZIP2 Antibody ASC11244
    Immunofluorescence of ZIP2 in human brain tissue with ZIP2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NP94
Other Accession NP_055394, 156415986
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32742 Da
Application Notes ZIP2 antibody can be used for detection of ZIP2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 29986
Target/Specificity SLC39A2;
Reconstitution & Storage ZIP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZIP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC39A2
Synonyms ZIP2
Function Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed only in prostate and uterine epithelial cells
Research Areas
Citations (0)

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ZIP2 Antibody: The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.


Gaither LA and Eide DJ. Functional expression of the human hZIP2 zinc transporter. J. Biol. Chem.2000; 275:5560-4.
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Kambe T, Geiser J, Lahner B, et al. Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am. J. Physiol. Regul. Integr. Comp. Physiol.2008; 294:R1474-81.

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$ 310.00
Cat# ASC11244
(40 western blots)
Availability: 5-7days
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