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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ZIP5 Antibody   

ZIP5 Antibody

     
  • WB - ZIP5 Antibody ASC11246
    Western blot analysis of ZIP5 in human spleen tissue lysate with ZIP5 antibody at 1 µg/mL.
  • IHC - ZIP5 Antibody ASC11246
    Immunohistochemistry of ZIP5 in human spleen tissue with ZIP5 antibody at 2.5 µg/mL.
  • IF - ZIP5 Antibody ASC11246
    Immunofluorescence of ZIP5 in human spleen tissue with ZIP5 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q6ZMH5
Other Accession NP_001128667, 206597541
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 56461 Da
Application Notes ZIP5 antibody can be used for detection of ZIP5 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 283375
Target/Specificity SLC39A5;
Reconstitution & Storage ZIP5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsZIP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC39A5
Synonyms ZIP5
Function May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity).
Cellular Location Basolateral cell membrane; Multi-pass membrane protein
Tissue Location Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney
Research Areas
Citations (0)

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Background

ZIP5 Antibody: The zinc transporter ZIP5, also known as SLC39A5, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP5 is closely related to ZIP4, and is found in many of the same tissues, including intestine, pancreas, liver, and kidney, but unlike ZIP4, ZIP5 localizes to the basolateral membrane in kidney cells and its activity is not downregulated by zinc repletion. Recent evidence suggests that ZIP4 and ZIP5 are reciprocally regulated, with translation of ZIP5 mRNA decreasing and ZIP5 protein being rapidly internalized and degraded in response to zinc deficiency.

References

Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Wang F, Kim BE, Petris MJ, et al. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J. Biol. Chem.2004; 279:51433-41.

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$ 310.00
Cat# ASC11246
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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