|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_001121697, 190014617|
|Calculated MW||39011 Da|
|Application Notes||ZIP13 antibody can be used for detection of ZIP13 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||Slc39a13; At least two isoforms of ZIP13 are known to exist; this antibody will detect both isoforms. ZIP13 antibody is predicted to not cross-react with other ZIP family members.|
|Reconstitution & Storage||ZIP13 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ZIP13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a zinc-influx transporter.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways.
Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Giunta C, Elcioglu NH, Albrecht B, et al. Spondylocheiro dysplastic form of Ehlers-Danlos syndrome - an autosomal recessive entity caused by mutations in the zinc transporter SLC39A13. Am. J. Hum. Genet.2008; 82:1290-305.
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