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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   LRRTM4 Antibody   

LRRTM4 Antibody

  • WB - LRRTM4 Antibody ASC11277
    Western blot analysis of LRRTM4 in HeLa cell lysate with LRRTM4 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - LRRTM4 Antibody ASC11277
    Immunohistochemistry of LRRTM4 in human brain tissue with LRRTM4 antibody at 2.5 µg/mL.
  • IF - LRRTM4 Antibody ASC11277
    Immunofluorescence of LRRTM4 in human brain tissue with LRRTM4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86VH4
Other Accession NP_001128217, 156139147
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 67217 Da
Application Notes LRRTM4 antibody can be used for detection of LRRTM4 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 80059
Target/Specificity LRRTM4; At least two isoforms of LRRTM4 are known to exist; this antibody will both isoforms. LRRTM4 antibody is predicted to not cross-react with other LRRTM family members.
Reconstitution & Storage LRRTM4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsLRRTM4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in neuronal tissues.
Research Areas
Citations (0)

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LRRTM4 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Little is known about the function of LRRTM4; in mouse, it is expressed in the limb mesenchyme, neural tube, caudal mesoderm and in three distinct regions of the head. Later expression occurs in a subset of the developing sclerotome. Its similarity to other LRRTM family members suggests that LRRTM4 may also play a role in the development and maintenance of the vertebrate nervous system.


Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.
Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.
Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.
Haines BP and Rigby PW. Developmentally regualted expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.

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$ 310.00
Cat# ASC11277
(40 western blots)
Availability: 5-7days
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