|Application ||WB, E|
|Other Accession||NP_1769, 21361571|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27683 Da|
|Application Notes||SLAMF2 antibody can be used for detection of SLAMF2 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||CD48; Two isoforms of SLAMF2 are known to exist; this antibody will recognize both isoforms. SLAMF2 antibody is predicted to not cross-react with other SLAM protein family members.|
|Reconstitution & Storage||SLAMF2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SLAMF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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Provided below are standard protocols that you may find useful for product applications.
SLAMF2 Antibody: The signaling lymphocyte-activation molecule family member 2 (SLAMF2), also known as CD48, is a GPI-anchored protein that exists as both a soluble and membrane-associated form and is expressed in almost all leukocyte populations particularly in mitogen-stimulated human lymphocytes. SLAMF2 is a high-affinity ligand for SLAMF4, also known as 2B4, as well as a low-affinity ligand for CD2, and can thus can stimulate cells expressing these receptors. It has been shown to be an IL-3-induced activating receptor on eosinophils and is likely to be involved in promoting allergic inflammation. SLAMF2 is also thought to be involved in the IL-18/IL-18R signaling cascade in T and natural killer cells to produce interferon-gamma.
Smith GM, Biggs J, Norris B, et al. Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis. J. Clin. Immunol. 1997; 17:502-9.
Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.
Munitz A, Bachelot I, Eliashar R, et al. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J. Immunol. 2006; 177:77-83.
Fukushima K, Ikehara Y, and Yamashita K. Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. J. Biol. Chem. 2005; 280:18056-62.
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