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ATP2C1 Antibody

  • WB - ATP2C1 Antibody ASC11314
    Western blot analysis of ATP2C1 in mouse brain tissue lysate with ATP2C1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - ATP2C1 Antibody ASC11314
    Immunohistochemistry of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 5 µg/mL.
  • IF - ATP2C1 Antibody ASC11314
    Immunofluorescence of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P98194
Other Accession NP_001001486, 312836765
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 100577 Da
Application Notes ATP2C1 antibody can be used for detection of ATP2C1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 27032
Target/Specificity ATP2C1; At least four isoforms of ATP2C1 are known to exist; this antibody will recognize only the three longest isoforms. ATP2C1 antibody will not cross-react with ATP2C2.
Reconstitution & Storage ATP2C1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsATP2C1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP2C1
Synonyms KIAA1347, PMR1L
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney
Research Areas
Citations (0)

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ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.


Hu Z, Bonifas JM, Beech J, et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat. Genet. 2000; 24:61-5
Dode L, Andersen JP, Vanoevelen J, et al. Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses. J. Biol. Chem. 281:3182-9.
Grice DM, Vetter I, Faddy HM, et al. Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J. Biol. Chem. 2010; 285:37458-66

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$ 310.00
Cat# ASC11314
(40 western blots)
Availability: 5-7days
Bulk Size
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