|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_057551, 189458852|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||17371 Da|
|Application Notes||ORMDL1 antibody can be used for detection of ORMDL1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||ORMDL1; ORMDL1 antibody may cross-react with other ORMDL protein family members.|
|Reconstitution & Storage||ORMDL1 antibody can be stored at 4 ℃, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||ORMDL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of sphingolipid synthesis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung|
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Provided below are standard protocols that you may find useful for product applications.
ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.
Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3(6): RESEARCH0027
Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α-secretase function. FASEB J. 2007; 22: 819-827
Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473
Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463(7284):1048-53
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