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ORMDL1 Antibody

  • WB - ORMDL1 Antibody ASC11327
    Western blot analysis of ORMDL1 in SK-N-SH Cell lysate with ORMDL1 antibody at (A) 1 µg/mL and (B) 2 µg/mL.
  • IHC - ORMDL1 Antibody ASC11327
    Immunohistochemistry of ORMDL1 in mouse brain tissue with ORMDL1 antibody at 5 µg/mL.
  • IF - ORMDL1 Antibody ASC11327
    Immunofluorescence of ORMDL1 in mouse brain tissue with ORMDL1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P0S3
Other Accession NP_057551, 189458852
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 17371 Da
Application Notes ORMDL1 antibody can be used for detection of ORMDL1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 94101
Target/Specificity ORMDL1; ORMDL1 antibody may cross-react with other ORMDL protein family members.
Reconstitution & Storage ORMDL1 antibody can be stored at 4 ℃, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsORMDL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Negative regulator of sphingolipid synthesis.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung
Citations (0)

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ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.


Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3(6): RESEARCH0027
Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α-secretase function. FASEB J. 2007; 22: 819-827
Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473
Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463(7284):1048-53

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$ 330.00
Cat# ASC11327
Availability: 5-7days
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