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Translin Antibody

  • WB - Translin Antibody ASC11331
    Western blot analysis of Translin in rat lung tissue lysate with Translin antibody at (A) 0.5 and (B) 1 µg/mL
  • IHC - Translin Antibody ASC11331
    Immunohistochemistry of Translin in human lung tissue with Translin antibody at 5 µg/mL.
  • IF - Translin Antibody ASC11331
    Immunofluorescence of Translin in human lung tissue with Translin antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15631
Other Accession NP_004613, 4759270
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 26183 Da
Application Notes Translin antibody can be used for detection of Translin by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 7247
Target/Specificity TSN; At least two isoforms of Translin are known to exist; this antibody will detect both.
Reconstitution & Storage Translin antibody can be stored at 4 ℃, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTranslin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSN
Function DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Cellular Location Cytoplasm. Nucleus
Citations (0)

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Translin Antibody: Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.


Aoki K, Susuki K, Sugano T, et al. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nat. Genet. 1995; 10:167-74.
Li Z, Wu Y, and Baraban JM. The Translin/Trax RNA binding complex: clues to function in the nervous system. Biochim. Biophys. Acta 2008; 1779:479-85

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$ 310.00
Cat# ASC11331
(40 western blots)
Availability: 5-7days
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