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TMEM88 Antibody

  • WB - TMEM88 Antibody ASC11345
    Western blot analysis of TMEM88 in human brain tissue lysate with TMEM88 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - TMEM88 Antibody ASC11345
    Immunohistochemistry of TMEM88 in mouse brain tissue with TMEM88 antibody at 2.5 µg/mL.
  • IF - TMEM88 Antibody ASC11345
    Immunofluorescence of TMEM88 in mouse brain tissue with TMEM88 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6PEY1
Other Accession EAW90125, 44662813
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 17251 Da
Application Notes TMEM88 antibody can be used for detection of TMEM88 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 92162
Target/Specificity TMEM88; At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.
Reconstitution & Storage TMEM88 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTMEM88 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM88
Synonyms TMEM88A
Function Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
Cellular Location Cell membrane; Multi-pass membrane protein
Citations (0)

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TMEM88 Antibody: Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.


Lee HJ, Finklestein D, Li X, et al. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J. Biol. Chem. 2010; 285:41549-56.

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$ 310.00
Cat# ASC11345
(40 western blots)
Availability: 5-7days
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