|Application ||WB, IF, ICC, E|
|Other Accession||NP_001138500, 222537747|
|Calculated MW||71695 Da|
|Application Notes||Paralemmin3 antibody can be used for detection of Paralemmin3 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||PALM3; At least two isoforms of Paralemmin3 are known to exist; this antibody will only detect the longer isoform|
|Reconstitution & Storage||Paralemmin3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||Paralemmin3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.|
|Cellular Location||Cytoplasm. Cell membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
Paralemmin3 Antibody: Paralemmin3 is a recently identified protein that associates with the single immunoglobulin IL-1 receptor-related molecule (SIGIRR), a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Silencing of Paralemmin3 expression by RNAi inhibited the release of inflammatory cytokines in A549 cells after stimulation with lipopolysaccharide (LPS), suggesting Paralemmin3 may function as an adaptor in the LPS-TLR4 signaling pathway.
Chen X, Wu X, Zhao Y, et al. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. Biochem. Biophys. Res. Commun. 2011; 404:1029-33
Wald D, Qin J, Zhao Z, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 2003; 4:920-7.
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