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FCHSD1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86WN1 |
| Other Accession | NP_258260, 89848 |
| Reactivity | Human, Mouse |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Calculated MW | 76942 Da |
| Application Notes | FCHSD1 antibody can be used for detection of FCHSD1 by Western blot at 0.5 - 1 μg/mL. |
| Gene ID | 89848 |
|---|---|
| Target/Specificity | FCHSD1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human FCHSD1. The immunogen is located within the last 50 amino acids of FCHSD1. |
| Reconstitution & Storage | FCHSD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | FCHSD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCHSD1 |
|---|---|
| Function | Promotes actin polymerization mediated by SNX9 and WASL. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6PFY1}. Perikaryon {ECO:0000250|UniProtKB:Q6PFY1}. Cell projection {ECO:0000250|UniProtKB:Q6PFY1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6PFY1}. Note=Detected on neuronal cell bodies and cell projections, in part on cytoplasmic vesicles {ECO:0000250|UniProtKB:Q6PFY1} |
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Provided below are standard protocols that you may find useful for product applications.
Background
FCHSD1 Antibody: The FCH and double SH3 domains protein 1 (FCHSD1, also known as NWK2) and the related protein FCHSD2 were initially identified in silico as distantly related proteins to FNBP1 and FNBP2. Both share the common domain structure consisting of FCH, FBH, two SH3 and C-terminal proline-rich domains. While little is known of the function of FCHSD1, the related protein NWK is an adaptor protein that is thought to regulate Rho activity downstream of Robo receptors, suggesting that FCHSD1 may be involved in synaptic morphology by regulating actin dynamics in presynaptic terminals.
References
Kato M and Kato M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int. J. Mol. Med. 2004; 13:749-54.
Coyle IP, Koh YH, Lee WC, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in drosophila. Neuron 2004; 41:521-34
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