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TSHZ3 Antibody

  • WB - TSHZ3 Antibody ASC11452
    Western blot analysis of TSHZ3 in mouse brain tissue lysate with TSHZ3 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - TSHZ3 Antibody ASC11452
    Immunohistochemistry of TSHZ3 in mouse brain tissue with TSHZ3 antibody at 2.5 µg/mL.
  • IF - TSHZ3 Antibody ASC11452
    Immunofluorescence of TSHZ3 in mouse brain tissue with TSHZ3 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63HK5
Other Accession NP_065907, 127138957
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 118566 Da
Application Notes TSHZ3 antibody can be used for detection of TSHZ3 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Additional Information
Gene ID 57616
Target/Specificity TSHZ3;
Reconstitution & Storage TSHZ3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTSHZ3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSHZ3
Synonyms KIAA1474, TSH3, ZNF537
Function Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus.
Tissue Location Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease
Citations (0)

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TSHZ3 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.


Caubit X, Core N, Boned A, et al. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Mech. Dev. 2000; 91:445-8.
Santos JS, Fonseca NA, Vieira CP, et al. Phylogeny of the Teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3 in the zebrafish. Dev. Dyn. 2010; 239:1010-8.
Caubit X, Tiveron MC, Cremer H, et al. Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J. Comp. Neurol. 2005; 486:76-88.
Kajiwara Y, Akram A, Katsel P, et al. FE65 binds teashirt, inhibiting expression of the primate-specific caspase-4. PLoS One 2009; 4:e5071

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$ 310.00
Cat# ASC11452
(40 western blots)
Availability: 5-7days
Bulk Size
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