|Application ||WB, E|
|Other Accession||NP_689922, 63025200|
|Calculated MW||110962 Da|
|Application Notes||STOX1 antibody can be used for detection of STOX1 by Western blot at 1 µg/mL.|
|Target/Specificity||STOX1; STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the two longest isoforms.|
|Reconstitution & Storage||STOX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||STOX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform A: Cytoplasm. Nucleus. Note=Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells Isoform C: Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
STOX1 Antibody: STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.
Van Dijk M, van Bezu J, Chim SS, et al. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005; 37:514-9.
Kivinen K, Peterson H, Hiltunen L, et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007;15:494-7.
Van Dijk M, van Bezu J, van Abel D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol. Genet. 2010; 19:2658-67.
Van Abel D, Hölzel DR, Jain S, et al. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLoS One 2011; 6 :e21994.
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