|Application ||WB, IF, E|
|Other Accession||NP_055840, 60498973|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||130 kDa|
|Application Notes||MYT1L antibody can be used for detection of MYT1L by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||MYT1L; At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.|
|Reconstitution & Storage||MYT1L antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||MYT1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
MYT1L Antibody: The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.
Romm E, Nielsen JA, Kim JG, et al. Myt1 family recruits histone deacetylase to regulate neural transcription. J. Neurochem. 2005; 93:1444-53
Li W, Wang X, Zhao J, et al. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav. 2012; 11:87-93.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.