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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   LMX1A Antibody   

LMX1A Antibody

  • WB - LMX1A Antibody ASC11569
    Western blot analysis of LMX1A in rat brain tissue lysate with LMX1A antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - LMX1A Antibody ASC11569
    Immunohistochemistry of LMX1A in human brain tissue with LMX1A antibody at 2.5 µg/mL.
  • IF - LMX1A Antibody ASC11569
    Immunofluorescence of LMX1A in human brain tissue with LMX1A antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TE12
Other Accession NP_796372, 28893581
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 42 kDa
Application Notes LMX1A antibody can be used for detection of LMX1A by Western blot at 1 - 2 µg/mL. Antibody can also be used for Immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 4009
Target/Specificity LMX1A; At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.
Reconstitution & Storage LMX1A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsLMX1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMX1A
Function Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis
Research Areas
Citations (0)

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LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.


Failli V, Bachy I and Retaux S. Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system. Mech. Dev. 2002; 118:225-8.
Nakatani T, Kumai M, Mizuhara E, et al. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Dev. Biol. 2010; 339:101-13.
Chizhikov VV and Millen KJ. Control of roof plate formation by LMX1A in the developing spinal cord. Development 2004; 131:2693-705.
Lin CK, Chao TK, Lai HC, et al. LMX1A as a prognostic marker in ovarian mucinous cystadenocarcinoma. Am. J. Clin. Pathol. 2012; 137:971-7.

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$ 310.00
Cat# ASC11569
(40 western blots)
Availability: 5-7days
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