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SIDT2 Antibody

  • WB - SIDT2 Antibody ASC11591
    Western blot analysis of SIDT2 in mouse brain tissue lysate with SIDT2 antibody at (A) 0.5 and (B) 1 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NBJ9
Other Accession NP_001035545, 94721340
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 92 kDa
Application Notes SIDT2 antibody can be used for detection of SIDT2 by Western blot at 0.5 - 1 µg/mL.
Additional Information
Gene ID 51092
Target/Specificity SIDT2; Multiple isoforms of SIDT2 are known to exist; this antibody is predicted to not cross-react with other members of the SID1 transmembrane family.
Reconstitution & Storage SIDT2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSIDT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIDT2
Function Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).
Cellular Location Lysosome membrane; Multi- pass membrane protein. Cell membrane. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980) Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity) {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980}
Research Areas
Citations (0)

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SIDT2 Antibody: The SID1 transmembrane family member (SIDT2) is a highly glycosylated, multipass transmembrane protein that localizes to the lysosomal membrane. SIDT2 is highly expressed in liver, brain and kidney, with no or little expression in skeletal muscles, heart or other tissues. Little is known of the function of SIDT2.


Jialin G, Xuefan G, and Huiwen Z. SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal membrane protein. Biochem. Biophys. Res. Commun. 2010; 402:588-94.

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$ 330.00
Cat# ASC11591
Availability: 5-7days
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