|Application ||WB, IHC-P, E|
|Other Accession||NP_000576, 10835153|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||18 kDa|
|Application Notes||IL-15 antibody can be used for detection of IL-15 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||IL15; At least two isoforms of IL-15 are known to exist.|
|Reconstitution & Storage||IL-15 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IL-15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.|
|Cellular Location||Isoform IL15-S48AA: Secreted.|
|Tissue Location||Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus|
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Provided below are standard protocols that you may find useful for product applications.
IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.
Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.
Ku CC, Murakami M, Sakamoto A, et al. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000; 288:675-8.
Waldmann T, Tagaya Y, and Bamford R. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998; 16:205-26.
Masuda A, Matsuguchi T, Yamaki K, et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediate Bcl-xL expression. J. Biol. Chem. 2001; 276:26107-13.
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