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IL-15 Antibody

  • WB - IL-15 Antibody ASC11615
    Western blot analysis of IL-15 in rat spleen tissue lysate with IL-15 antibody at (A) 1 and (B) 2 µg/mL
  • IHC - IL-15 Antibody ASC11615
    Immunohistochemistry of IL-15 in spleen tissue with IL-15 antibody at 2.5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40933
Other Accession NP_000576, 10835153
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 18 kDa
Application Notes IL-15 antibody can be used for detection of IL-15 by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 3600
Target/Specificity IL15; At least two isoforms of IL-15 are known to exist.
Reconstitution & Storage IL-15 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL15
Function Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Cellular Location Isoform IL15-S48AA: Secreted.
Tissue Location Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus
Research Areas
Citations (0)

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IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.


Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.
Ku CC, Murakami M, Sakamoto A, et al. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000; 288:675-8.
Waldmann T, Tagaya Y, and Bamford R. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998; 16:205-26.
Masuda A, Matsuguchi T, Yamaki K, et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediate Bcl-xL expression. J. Biol. Chem. 2001; 276:26107-13.

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$ 310.00
Cat# ASC11615
(40 western blots)
Availability: 5-7days
Bulk Size
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