|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_002978, 4506829|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||10 kDa|
|Application Notes||CCL17 antibody can be used for detection of CCL17 by Western blot at 1 - 2 µg/mL.|
|Reconstitution & Storage||CCL17 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||CCL17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.|
|Tissue Location||Expressed at high levels in thymus and at low levels in the lung, colon and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
CCL17 Antibody: CCL17, also known as TARC, binds to chemokine receptors CCR4 and CCR8 and plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. CCL17 is secreted from monocyte-derived DCs and endothelial cells and is responsible for selective recruitment and migration of activated Th2 lymphocytes. CCL17 is also required for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells under inflammatory conditions.
Imai T, Baba M, Nishimura M, et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997; 272:15036-42.
Bernardini G, Hedrick J, Sozzani S, et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur. J. Immunol. 1998; 28:582-8.
Alferink J, Lieberam I, Reindl W, et al. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 2003; 197:585-99.
Stutte S, Quast T, Gerbitzki N, et al. Requirement of CCL17 for CCR7 and CXCR4-dependent migration of cutaneous dendritic cells. Proc. Natl. Acad. Sci. USA 2010; 107:8736-41.
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