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PRKCDBP Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q969G5 |
| Other Accession | NP_659477, 47132587 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 29 kDa |
| Application Notes | PRKCDBP antibody can be used for detection of PRKCDBP by Western blot at 1 - 2 µg/mL. |
| Gene ID | 112464 |
|---|---|
| Target/Specificity | PRKCDBP; It is predicted to not cross-react with other members of the cavin family. |
| Reconstitution & Storage | PRKCDBP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | PRKCDBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAVIN3 (HGNC:9400) |
|---|---|
| Synonyms | PRKCDBP, SRBC |
| Function | Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner. |
| Tissue Location | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PRKCDBP Antibody: The protein kinase C delta (PKC-δ) binding protein (PRKCDBP), also known as cavin-3, is a member of the cavin family of proteins that are involved in caveolin formation and regulation. PRKCDBP was initially identified in a screen of cultured cell lines for proteins that were strongly induced by serum starvation. Studies indicate that PRKCDBP binds not only to PKC-δ but also to caveolin-1 and helps regulate caveolin traffic and function. Similar to other members of the cavin family, the expression of PRKCDBP was found to be down-regulated in various cancer cell lines, suggesting a possible tumor suppressor function of PRKCDBP.
References
Briand N, Dugail I, and Le Lay S. Cavin proteins: New players in the caveolae field. Biochimie 2011; 93:71-7.
Izumi Y, Hirai S, Tamai Y, et al. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. J. Biol. Chem. 1997; 272:7381-9.
McMahon K, Zajicek H, Li W, et al. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J. 2009; 28:1001-15.
Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.
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