|Application ||WB, IHC-P, E|
|Other Accession||NP_079474, 21314736|
|Calculated MW||Predicted: 42 kDa |
Observed: 40 kDa
|Application Notes||MTERFD3 Antibody can be used for detection of MTERFD3 by Western blot at 1 µg/mL.|
|Target/Specificity||MTERFD3; MTERFD3 antibody is predicted to not cross-react with other MTERFD protein family members.|
|Reconstitution & Storage||MTERFD3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||MTERFD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).|
|Cellular Location||Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid|
|Tissue Location||Expressed in skeletal muscle, heart, liver and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
MTERFD3 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD3 was initially identified through differential display analysis and is expressed primarily in heart, liver, pancreas and skeletal muscle. MTERFD3 is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription, and may be a serum-inhibitory factor.
Fernandez-Silva P, et al. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 1997; 16:1066-79.
Chen Y, Zhou G, Yu M, et al. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. Biochem. Biophys. Res. Commun. 2005; 337:1112-8.
Park CB, Asin-Cayuela J, Camara Y, et al. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007; 130:273-85.
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