|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_075069, 281182571|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 50 kDa |
Observed: 53 kDa
|Application Notes||TMEM135 Antibody can be used for detection of TMEM135 by Western blot starting at 1 µg/mL.|
|Target/Specificity||TMEM135; At least two isoforms of TMEM135 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||TMEM135 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TMEM135 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in peroxisome organization.|
|Cellular Location||Membrane; Multi-pass membrane protein. Peroxisome|
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Provided below are standard protocols that you may find useful for product applications.
TMEM135 Antibody: The transmembrane protein 135 (TMEM135), also known as peroxisomal membrane protein 52 (PMP52), was initially identified as a protein that might be critical for adipogenesis and osteoblastogenesis. Further studies have indicated that TMEM135 may be part of a regulatory circuit that plays an important role in fat metabolism and energy expenditure in both C. elegans as well as mammalian organisms. Finally, recent experiments has suggested that TMEM135 may be an additional driver of breast cancer.
Scheideler M, Elabd C, Zaragosi LE, et al. Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics 2008; 9:340.
Exil VJ, Avila DS, Benedetto A, et al. Stress-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longetivity regulation in Caenorhabditis elegans. PLoS One 2010; 5:e14228.
Natrajan R, Mackay A, Lambros MB, et al. A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and –positive breast cancers. J. Pathol. 2012; 227:29-41.
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