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TMEM135 Antibody

     
  • WB - TMEM135 Antibody ASC11639
    Western blot analysis of TMEM135 in rat liver tissue lysate with TMEM135 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - TMEM135 Antibody ASC11639
    Immunohistochemistry of TMEM135 in human liver tissue with TMEM135 antibody at 2.5 µg/ml.
  • IF - TMEM135 Antibody ASC11639
    Immunofluorescence of TMEM135 in human liver tissue with TMEM135 antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q86UB9
Other Accession NP_075069, 281182571
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 50 kDa

Observed: 53 kDa
Application Notes TMEM135 Antibody can be used for detection of TMEM135 by Western blot starting at 1 µg/mL.
Additional Information
Gene ID 65084
Target/Specificity TMEM135; At least two isoforms of TMEM135 are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage TMEM135 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTMEM135 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM135
Function May be involved in peroxisome organization.
Cellular Location Membrane; Multi-pass membrane protein. Peroxisome
Research Areas
Citations (0)

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Background

TMEM135 Antibody: The transmembrane protein 135 (TMEM135), also known as peroxisomal membrane protein 52 (PMP52), was initially identified as a protein that might be critical for adipogenesis and osteoblastogenesis. Further studies have indicated that TMEM135 may be part of a regulatory circuit that plays an important role in fat metabolism and energy expenditure in both C. elegans as well as mammalian organisms. Finally, recent experiments has suggested that TMEM135 may be an additional driver of breast cancer.

References

Scheideler M, Elabd C, Zaragosi LE, et al. Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics 2008; 9:340.
Exil VJ, Avila DS, Benedetto A, et al. Stress-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longetivity regulation in Caenorhabditis elegans. PLoS One 2010; 5:e14228.
Natrajan R, Mackay A, Lambros MB, et al. A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and –positive breast cancers. J. Pathol. 2012; 227:29-41.

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$ 310.00
Cat# ASC11639
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