|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_001243371, 374253783|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 43 kDa |
Observed: 44 kDa
|Application Notes||PRRT2 Antibody can be used for detection of PRRT2 by Western blot at 1 µg/mL.|
|Target/Specificity||PRRT2; Multiple isoforms of PRRT2 are known to exist.|
|Reconstitution & Storage||PRRT2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||PRRT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse|
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Provided below are standard protocols that you may find useful for product applications.
PRRT2 Antibody: The proline-rich transmembrane protein 2 (PRRT2) contains a proline-rich domain in its N-terminal half and is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. While little is known of the function of this protein, mutations in PRRT2 have been shown to be the causative gene of paroxysmal kinesigenic dyskinesia, which is characterized by recurrent, brief attacks of abnormal involuntary movements induced by sudden voluntary movements. Recent studies have shown that PRRT2 may also be involved in some forms of benign familial infantile epilepsy (BFIE), an autosomal dominant epilepsy syndrome.
Wang JL, Cao L, Li XH, et al. Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain 2011; 134:3493-501.
Scheffer IE, Grinton BE, Heron SE, et al. PRRT2 phenotypic spectrum includes sporadic and fever-related infantile seizures. Neurology 2012; epub.
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